Predoctoral researcher at the Targeted Therapeutics & Nanodevices Research Group (Project BRAINZYME)

Overview

Proyecto de Generación de Conocimiento by the Spanish Ministry of Science, Innovation and Universities

The Targeted Therapeutics & NanodevicesGroup at the Institute for Bioengineering of Catalonia (IBEC) is looking for a Pre-doctoral Researcher to conduct her / his predoctoral training on the development and characterization of novel multifunctional biotherapeutics capable of crossing biological barriers in the body to efficiently reach their targets, using state-of-the-art bio-nano-technological and pharmaceutical sciences principles and methods. The aim of the project is to develop novel therapeutics for the treatment of fatal neurodegenerative diseases due to congenital enzymatic defects, easily translatable into broader applications.

The PhD project will be conducted in the framework of the project entitled : “New isoform-dependent brain-targeting for enzyme therapy” (BRAINZYME).

This fellowship is associated with the research project Generación de Conocimiento, funded by the Spanish Ministry of Science, Innovation and Universities.

Main tasks and responsibilities

• Help design multimodular biotherapeutics with capabilities such as pro-drug protection, specific targeting, precise transport, controlled release, and therapeutic activity.
• Characterize and optimize these biotherapeutics in vitro by assessing their structure, functionality, and stability under storage and physiological conditions.
• Examine their performance in 2D and 3D systems, including chemical and genetic disease models, multi-cultures and organ-on-a-chip devices.
• Investigate the biodistribution as well as therapeutic and unwanted side effects of these biotherapeutics in vivo using animal models.
• Implement quantitative / qualitative methods and analysis to obtain strong conclusions.
• Keep updated records of the implemented protocols, results, analyses, and data.
• Share / resent data with / to assigned supervisor(s), lab members and pertinent collaborators.
• Participate in the preparation / writing / presentation of scientific results for designated conferences, specialized journals and possible patent application processes.
• Help others with general lab-keeping tasks, such as inventory logs, ordering, instrument maintenance, space organization, collaborations, safety regulations, and maintaining a high scientific standard and collegial atmosphere for proper well-being of the lab members.

Requirements for candidates

Essential :

Preferable / advantageous :

We Offer

How to apply

Applications should be submitted before the deadline. Reference : FPI_SM. For questions regarding your application, contact

Principles and equal opportunity

IBEC is committed to the principles of the Code of Conduct for the Recruitment of Researchers of the European Commission and the Open, Transparent and Merit-based Recruitment principles (OTM-R).

IBEC’s Commitment on equal opportunity, diversity, and inclusion : IBEC is an equal opportunity employer and supports diversity and inclusion across gender, nationality, religion, disabilities, age, sexual identity or cultural and socioeconomic background.

IBEC follows GDPR and data protection requirements in the recruitment process.

Who we are

The Institute for Bioengineering of Catalonia, IBEC, is an interdisciplinary research center focused on Bioengineering and Nanomedicine based in Barcelona. IBEC is a Severo Ochoa Research Centre for excellence.

IBEC is located within the Barcelona Science Park and manages extensive facilities and a diverse team of researchers from multiple countries.

Grant PID OB-I00 funded by MICIU / AEI / / and FEDER, EU.

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