Postdoctoral Research Assistant for the Biomolecular Design and Structural Nanomedicine Group ([...]

Descripción We are looking for a Postdoctoral Researcher to join Roger Castells-Graells’ lab at the Spanish National Cancer Research Centre (CNIO). The successful candidate will work on innovative biomolecular designs for biomedical and cryo-electron microscopy (cryo-EM) applications, utilizing protein design, structural biology, and AI-driven tools. This research builds on recent advancements in protein design (Castells-Graells et al., 2023; Meador et al., 2024).

We are looking for a motivated and passionate scientist excited to contribute to groundbreaking research in a collaborative and supportive environment. The ideal candidate will hold a PhD in a relevant field, with expertise in one or more of the following areas : biochemistry, protein design, virology, structural biology, machine learning or cryo-electron microscopy (cryo-EM). Additional training and development opportunities will be provided.

This fully funded position is ideal for researchers who have recently completed their doctoral studies or are looking to further develop their research skills. At CNIO, you will have the opportunity to work with world-class scientists in an institute renowned for its excellent facilities and high-quality research. In the Biomolecular Design and Structural Nanomedicine lab (PI : Roger Castells-Graells), we combine protein design, structural biology, and synthetic biology, leveraging AI-driven approaches to engineer protein cages, nanomachines, and other biomolecules with precise functions. By integrating these innovations with detailed studies of viral structures, we explore new ways to manipulate biological systems. Our goal is to translate these advances into nanomedicine, developing cutting-edge imaging tools for cryo-EM and therapeutic platforms that address critical challenges in cancer and human health.

For informal inquiries, you can contact Dr. Roger Castells-Graells ( ), Dr. Oscar Llorca ( ) and more information can be found at : financiación de estos contratos procede del Mecanismo de Recuperación y Resiliencia de la Unión Europea-Next Generation, en el marco de la Invitación General de la entidad pública empresarial Red.es para participar en los programas de atracción y retención del talento dentro de la Inversión 4 del Componente 19 del Plan de Recuperación, Transformación y Resiliencia.”

Criterios de evaluación We are seeking an enthusiastic and motivated scientist with the following qualifications and experience :

Essential Qualifications and Skills PhD in molecular biology, biochemistry, bioengineering, biophysics, computational biology, bioinformatics, machine learning, artificial intelligence, or a related discipline.

Experience in one or more of the following areas : protein biochemistry, molecular biology, virology, cryo-electron microscopy (cryo-EM), or machine learning.

Excellent communication and teamwork skills.

Fluency in English.

Desirable Experience and Skills Experience with Python and other programming languages is a plus.

Experience in data analysis of single-particle cryo-EM images and / or tomography data is a plus.

Hands-on experience with cryo-focused ion beam scanning electron microscopy (cryo-FIB / SEM) is a plus.

Application materials should include :

Curriculum Vitae.

Cover letter.

Contact details for 2-3 referees.

Se ofrece The opportunity to work at an internationally renowned cancer research center of excellence.

A collaborative, supportive, and inclusive work environment.

A competitive salary.

A fully funded contract linked to a research project.

Access to state-of-the-art facilities, including cryo-electron microscopes, high-performance computing resources, and expert guidance in both experimental and computational aspects of cryo-EM and protein design.

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