Director Drug Discovery Chemistry

DIRECTOR DRUG DISCOVERY – CHEMISTRY

Our client is a solid technology company, now managing an emerging biotech platform dedicated to discovering and developing breakthrough antimicrobial agents to combat the growing threat of drug-resistant infections. Leveraging cutting‐edge biology, advanced screening platforms, and a multidisciplinary team, they aim to deliver novel anti‐infective therapies with transformative potential for global health.

Driven by a strong scientific and entrepreneurial spirit, the company is entering an exciting research & growth phase. We are now seeking a Director, Drug Discovery Chemistry, to lead and expand their Discovery Chemistry function, driving innovation, collaboration, and scientific excellence across their pipeline.

Main Responsibilities :

Directly supervise and manage the day‐to‐day activities of the Research Chemistry group, providing vision, inspiration, and both short‐term and long‐term goals. Communicate priorities, policies, and goals of Senior Leaders to the group.

Perform medicinal chemistry SAR‐driven optimization of novel small molecule and other drug modalities to provide overall optimal in vitro and in vivo properties of new anti‐infective therapeutics

Champion and lead the Research chemistry efforts on multiple internal / external project teams, and demonstrate the ability to multi‐task and parallel process to add to our continuous pipeline of development candidates

Identify new strategies and technologies and improve on existing platforms for pursuing novel synthesis of small molecule and other drug modalities

Set priorities, accelerate, and ensure successful progression of the group's technology and pipeline projects.

Actively participate in departmental, cross‐functional, senior leadership, and external meetings to contribute expertise and to represent the goals and vision of the Discovery Chemistry group.

Interact broadly and collaboratively with other groups, forging relationships and active collaborations.

Challenge and mentor the Drug Discovery Chemistry group to provide opportunities, visibility, and development for all group members.

Directly report to the General Manager.

Required Qualifications & Experience :

Have a Ph.D. in synthetic organic chemistry or in medicinal chemistry (Ph.D. in Chemistry or Pharmacy).

Extensive drug discovery experience with small molecule and other drug modalities including their synthesis and manufacturing, and expertise in modern methods in medicinal chemistry structure‐activity relationships.

A minimum of 10 years of industry experience.

Additional relevant experience should include an understanding of biological MOAs, extracellular / intracellular target evaluation, ADME / PK, PD / efficacy, tox evaluation,

A track record of success in the field of novel therapeutic molecules, (i.e., advancement of molecules into the clinic)

Experience building leading teams is required.

Working collaboratively with both internal and external organizations (e.g., CROs) is mandatory.

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