Global Regulatory Affairs Manager

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the CRG received the renewal of the ‘HR Excellence in Research’ Award from the European Commission. This is a recognition of the Institute’s commitment to developing an HR Strategy for Researchers, designed to align practices and procedures with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers.

The Role

We are seeking a motivated postdoctoral scientist interested in dissecting genome regulatory mechanisms underlying human diabetes. The successful applicant will develop cell-based model systems such as human stem cell-derived beta cells, using single-cell genomic read-outs, and will explore poorly understood genome regulatory mechanisms. The work will be performed within a multidisciplinary lab located in the CRG.

About the Lab

The Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus and to develop therapeutic avenues. The group is particularly interested in understanding how genomic information directs cell-specific gene expression and pinpoints gene regulatory defects underlying human disease.

The team brings together diverse expertise, including work with mutant stem cell-derived beta cell organoids, engineered mouse models, single-cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data. This multidisciplinary approach creates unique opportunities for collaborative projects that combine experimental and computational methods. The lab encourages wet lab scientists to engage in their own data analysis and provides a supportive environment for this end. The group is funded by the European Research Council, the Spanish Ministry of Science and Innovation, Generalitat de Catalunya, an AXA chair, European Foundation for the Study of Diabetes, the Marie Skłodowska-Curie Actions program, and a CIBERDEM diabetes network. The lab forms part of international consortia focused on advancing research in regulatory genomics, single-cell genomics, and human genetics.

Recent Studies from the Lab Include :

• A lineage-specific gene transcription and splicing hierarchy disrupted in type 2 diabetes (In review)
• Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes (In review)
• Transcription regulation by long non-coding RNAs and their disease relevance (Nat Rev Mol Cell Biol, 2024)
• HASTER lncRNA promoter as a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol, 2022)
• Pancreas agenesis mutations disrupting a lead enhancer controlling a developmental enhancer cluster (Dev Cell, 2022)
• Human pancreatic islet 3D chromatin architecture providing insights into the genetics of type 2 diabetes (Nat Genet, 2019).

Whom Would We Like to Hire?

Professional Experience

Education and Training

Languages

Technical Skills

Competences

The Offer – Working Conditions

We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities.

We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.

The CRG is committed to reconciling work and family life for its employees and offers an extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include :

All applications must be addressed to Dr. Jorge Ferrer and submitted online on the CRG Career site.

Selection Process

Pre-selection : The pre-selection process will be based on qualifications and expertise reflected in the candidates' CVs. It will be merit-based.

Interview : Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.

Offer Letter : Once the successful candidate is identified, the People department will send a Job Offer specifying the start date, salary, working conditions, among other important details.

Deadline : Please submit your application by January 31, 2025.

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